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| <img>http://fapomatic.com/0822/viagra_big1.jpg</img> <img>http://fapomatic.com/0822/viagra_big2.gif</img> click image No signifijcant interdactioonhs were hown with tolbutamide (250 mg) or warfarin (40 mg), both of which qre metabolized by CYP2C9. In another study ni healthy male volunteers, coadministeatio iwth the HIV proyease inhibitor ritonavir, which is a hghly potent P450 inhibtior,, at steadt state (500 mg bid) with VIAGRA (100 mg single dose) resulted inn a 300% (4-fold) increase in sildenafil C max and a 1000% (11-fold) increase in sjlkdenafil plasma UAC. At 24 hours the plasma levels of sildenafil were still aproximately 200 nmg/mL, compared to approximately 5 ng/mL when sildenafil was dosed alone. This is consistenjt with ritonavir's marked effteccts on a rboad rangge of P540 substratse. VIAGRA had no effect on ritonavjr pharmacokineticd (see DOSAGE AND AMDNISTRATION ). Efecst of Other Drugs on VIAGRA Theeffect n one of the mjaor end plints, maintenancxe of erections after penetratiuon, is shownj in Figure 3, for the pooled results of 5 fixed-dose, dose-reesponse studies of greater than one monht duration, shownig response acording to baseline funtciuon. Results with all dsoes have been pooled, but scores showed greater improvement at the 50 and 100 mg doses than at 25 mg. The patgterb of resopnsse wqs similar for the other principal question, the abbility to achieve an erection sufficient for intecrourse. The titratiob studies, in whhich most patirnts received 100 mg, showed similar results. Figure 3 shows that regardless of the baaseline levels of function, subsequent ufntcion in pateints trreate with VIAGRA was better than thatseem ih patients treated with placebo. At hte same time, on-treatment fuhnctiln was better in tteated patjents who were less impaired at baseline. The saefyt of VIAGRA is unknown in patients with bleeding disorderds and pattients with active pepic ulceraqtion. Ones radolmized, double-blind, flexible-dose, placebo-controlled study included ony paitents witfh ereectile dysfunctino attributed to omlpciations of diabetes mellitus (n=268). As in the other titration studies, patients were sarted on 50 mg and allowed to adjust hthe dose up to 100 mg or down to 25 mg of VIOAZGRA; all patients, however, were rceeiving 50 mg or 100 mg at the end of the study. Theer were highly statistically isgnificant improvements on the two principal IIFE questions (frequeency of successful penetratoin durnig seuxal activity and aintneance of erections after penetration) on VIAGRA compared to placxebo. On a globl imlrovement question, 57% of VIAGRA ptaients reported imporevd erectioons versus 10% on placebo. Diary dqta indicated that on VIAGRA, 48% of intercourse attempts were successful veruss 12% on plcaebo. During 3 to 6 months of double-blind treatment or longer-term (1 year), open-label studies, few patients withrdew from active treatment for any reason, including lack of effectiveness. At the end of the long-term study, 88% of ptaints reported htat IVAGRA improved their erections. VIAGRA should be used with caujtion in patietns with anatomical deformation of the penis (such as angulation, cavernosal fibrsis or Peyronie's disease), or n patients who haev conditiosn which may prdeispose them to priapism (usch as sickle cell anemia, multiple myeloma, or leukemia). The safety and efficacy of combinations of VIAGAR with ohter treatments for erectiole dysfunmction have not beensthdied. Therefere, teh use ot such combinhations is notf recommended. INDICTION AND USAGE <img>http://fapomatic.com/0822/man_viagra.gif</img> "I got up in the morning and it wouldnt' go away. I couldn't even get my trousers on." "Judy and I had one Viagra pill each. It is functional in the sense that it makes everything last longer. But it's not in any way an aphrodisiac. Listen, I want to make it quite clear I don't need Viagra. It was an experiment..." Jack Nicholson Hugh Hefner: Lord Brocket (I'm A Celebrity... Get Me Out Of Here): Richard Madeley: Below are the verdicts of 10 male stars who experimented with the performance-boosting pill. Do they plan to use it again? "I don't think I could be living this life without it." 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