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How to use Oral Prograf is taken twice daily. Doses vary widely and are based on blood tests that measure the amount of Prograf in the body. Taking Prograf with food can reduce some of the abdominal pain that can occur with this medicine; however, food can reduce the amount of Prograf that is absorbed. This is especially true with fatty foods. Thus, Prograf is best taken without food. If it must be taken with food, it should be taken with non-fatty food. Drug Class and Mechanism Prograf is a drug that suppresses the immune system and is used to prevent rejection of transplanted organs. Prograf accomplishes its immune-suppressing effecting by inhibiting an enzyme (calcineurin) crucial for the multiplication of T-cells, cells that are vital to the immune process. The use of oral Prograf allows transplantation specialists to reduce the dose of steroids which are also used to prevent rejection. 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