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 ■題名 : bbu.y vvi.ag.ra- z
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 ■日付 : 10/2/3(水) 16:56
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 and this : PMID: 15213306 Phosphorylation of phosphodiesterase-5 by cyclic nucleotide-dependent protein kinase alters its catalytic and allosteric cGMP-binding activities.US doctors undertook a review of published studies looking at the prevalence of the use of Viagra and its association with sexually transmitted infections, including HIV.To probe potential PDE5 R domain effects on catalytic site affinity for certain inhibitors, four N-terminal truncation mutants were generated: PDE5Delta1-321 contained GAF-B domain, C domain, and the sequence between GAF-A and -B; PDE5Delta1-419 contained GAF-B and C domain; PDE5Delta1-465 contained the C domain and the C-terminal portion of GAF-B; and PDE5Delta1-534 contained only C domain.Another prominent sex researcher Rosemary Basson MD of the University of British Columbia Canada agrees that the medical focus on desire is misplaced.There were PDE5A1 and PDE5A2 mRNA expressions in rat corpus cavernosum with PDE5A2 being the dominant isoform. G'night
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